Senior Clinical Research Associate

Senior Clinical Research Associate ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster. As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers. As a Senior Clinical Research Associate at ICON, you will be responsible for the monitoring and oversight of clinical trial sites, ensuring studies are conducted in accordance with the protocol, ICH GCP, and applicable regulatory requirements. You will be embedded within ICON Strategic Solutions, working in partnership with a sponsor to deliver high-quality clinical research across the study lifecycle. What You Will Do: In this role, you will take full ownership of investigator sites, leading monitoring activities and ensuring successful study delivery from start-up through to close-out. Key responsibilities include: Conduct site qualification, initiation, monitoring, and close-out visits across assigned studies Take full ownership of investigator sites, ensuring effective management in line with the Clinical Monitoring Plan (CMP) and study requirements Ensure investigator site compliance with study protocols, ICH GCP, SOPs, and applicable regulatory requirements Build and maintain strong, long-term relationships with investigators and site personnel, providing ongoing training and support Support study start-up activities, including essential document collection, regulatory submissions, and Ethics Committee interactions Identify site-level risks and drive corrective and preventive actions to ensure study quality and timelines Collaborate with cross-functional teams and support study delivery, including budget/contract discussions and informed consent development ​ Your Profile: To succeed in this role, you will bring strong clinical research experience, a proactive mindset, and the ability to work independently while maintaining high quality standards. Required qualifications and experience: A degree in life sciences or a related discipline Minimum of 5 years’ experience in clinical monitoring and investigator site management within a CRO or pharmaceutical environment Strong knowledge of ICH GCP, local, and international regulatory requirements Experience across the full trial lifecycle, including start-up, monitoring, and close-out activities Willingness and ability to travel up to 60% and hold a valid driver’s license, and be based in Johannesburg Experience in diabetes, cardiology, or obesity is advantageous Employment with ICON is contingent upon having the legal right to work in the country where the role is based. Rewards & Benefits ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development. Benefits may include: Competitive base salary and performance related incentives Health and wellbeing programmes including medical, dental, and vision coverage where applicable Retirement and pension plans Life assurance and disability coverage Employee assistance programmes and wellbeing resources Learning and development opportunities through structured training and career pathways Benefits may vary depending on role and location. Visit our careers site to read more about the benefits ICON offers. Inclusion and Accessibility ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported. If you require reasonable accommodations during the recruitment process, please let us know or submit a request here. Are you a current ICON Employee? Please click here to apply Apply To This Job